Study participant Sean O’Connell is given a shot in this undated handout photo. Canadian researchers have launched a study to determine if a century-old vaccine against tuberculosis can offer some protection against COVID-19. Investigators at the University Health Network in Toronto say they hope to test a theory that Bacille Calmette Guerin, or BCG, can reduce the incidence and severity of COVID-19 infection. THE CANADIAN PRESS/HO - University Health Network

Study participant Sean O’Connell is given a shot in this undated handout photo. Canadian researchers have launched a study to determine if a century-old vaccine against tuberculosis can offer some protection against COVID-19. Investigators at the University Health Network in Toronto say they hope to test a theory that Bacille Calmette Guerin, or BCG, can reduce the incidence and severity of COVID-19 infection. THE CANADIAN PRESS/HO - University Health Network

Canadian researchers explore whether TB vaccine offers COVID-19 protection

The trial is open to police, fire and health-care workers who are at greater risk of COVID-19 exposure

Canadian researchers have launched a study to determine if a century-old vaccine against tuberculosis can offer some protection against COVID-19.

Investigators at the University Health Network in Toronto say they hope to test a theory that Bacille Calmette Guerin, or BCG, can reduce the incidence and severity of COVID-19 infection.

The trial is open to police, fire and health-care workers who are at greater risk of COVID-19 exposure, with researchers hoping to recruit more than 3,600 participants.

Principal co-investigator Dr. Alexandre Zlotta says that if the inexpensive vaccine proves helpful, it can be rapidly deployed to offer temporary protection until a COVID-specific vaccine is widely available.

While BCG continues to be used in European and developing countries, Canada discontinued routine use in the early 1970s, according to Toronto Public Health.

Tuberculosis cases in Canada are among the lowest in the world, although certain vulnerable populations are at higher risk for the infectious, bacterial disease.

Dubbed “COBRA,” the double-blind placebo-controlled study is unfolding alongside trials in Germany and the United States. Experts expect to release results in May 2021.

Interest in BCG emerged early in the pandemic when researchers noticed some countries with higher rates of BCG coverage also had significantly lower rates of COVID-19 deaths. But more recent analysis reflecting the pandemic’s movement across the globe bucks that idea.

“Lack of evidence for BCG vaccine protection from severe COVID-19,” states the headline of a letter published in the Proceedings of the National Academy of Sciences on Sept. 29.

Citing updated analysis based on data from the Johns Hopkins University Coronavirus Resource Center, the study notes Bolivia, Panama, Columbia, Peru, Brazil, Mexico and South Africa had the largest increases in COVID-19 deaths on Aug. 1, even though the countries also have high BCG coverage.

The letter concludes by saying ongoing randomized controlled trials should provide more concrete answers.

UHN says the Canadian study uses an improved version of the vaccine, which researchers expect “will help muster a stronger immune response.”

“The big advantage here is this vaccine has been given to billions of people around the world in the past decades,” Zlotta says in a release.

“It is safe and readily available. If the study is successful, this could become an important strategy to control the secondary waves of the pandemic.”

The study is being funded by The Princess Margaret Cancer Foundation.

Cassandra Szklarski, The Canadian Press


Like us on Facebook and follow us on Twitter.

Want to support local journalism during the pandemic? Make a donation here.

Coronavirusvaccines

Get local stories you won't find anywhere else right to your inbox.
Sign up here

Just Posted

The Pacific Rim National Park Reserve is urging visitors to stay on designated trails after a hiker became injured in an unsanctioned area last week. (Westerly file photo)
Injured hiker rescued in Pacific Rim National Park Reserve

“Safety is everyone’s responsibility.”

People skate on a lake in a city park in Montreal, Sunday, January 10, 2021. THE CANADIAN PRESS/Graham Hughes
The end of hugs: How COVID-19 has changed daily life a year after Canada’s 1st case

Today marks the one year anniversary of COVID-19 landing in Canada

Janice and Martin Green are grateful for their town’s community paramedicine program. (Photo courtesy of Janice Green)
Community paramedicine program a lifesaver in Tofino-Ucluelet

“It makes us feel more comfortable here knowing that we do have emergency services that kick in.”

A Tla-o-qui-aht First Nation guardian took this photo of dozens of vehicles parked along a forest service road in the Kennedy watershed. (Submitted photo)
POLL QUESTION: Would you like to see stricter enforcement towards illegal camping?

Would you like to see stricter enforcement towards illegal camping? READ MORE:… Continue reading

A health-care worker prepares a dose of the Pfizer-BioNTech COVID-19 vaccine at a UHN COVID-19 vaccine clinic January 7, 2021. THE CANADIAN PRESS/Nathan Denette
Employers might be able to require COVID-19 vaccination from employees: B.C. lawyer

‘An employer must make the case’ using expert science, explains lawyer David Mardiros

Crews with Discovery Channel film as an Aggressive Towing driver moves a Grumman S2F Tracker aircraft around a 90-degree turn from its compound and onto the road on Saturday, Jan. 23, 2021. It was the “most difficult” part of the move for the airplane, one organizer said. (Jenna Hauck/ Chilliwack Progress)
VIDEO: Vintage military plane gets towed from Chilliwack to Greater Victoria

Grumman CP-121 Tracker’s eventual home the British Columbia Aviation Museum on Vancouver Island

Residents of the Cowichan Valley decorated more than 55 vehicles with anti-racist slogans for a car rally in support of Cowichan Tribes on Saturday, January 24. (Kevin Rothbauer/Citizen)
Dozens join anti-racism car rally and virtual panel in Cowichan Valley

Provincial ministry and BC Green caucus issue joint statement detailing concerns

Jesse Savidant, 31, is wanted by the RCMP after failing to appear in provincial court in Nanaimo in December. Police warn Savidant should be considered violent. (Photo Submitted)
Warrant out for man accused of stolen property offences across Vancouver Island

Jesse Savidant did not appear for court date in Nanaimo last month, say RCMP

Rolling seven-day average of cases by B.C. health authority to Jan. 21. Fraser Health in purple, Vancouver Coastal red, Interior Health orange, Northern Health green and Vancouver Island blue. (B.C. Centre for Disease Control)
2nd COVID vaccine doses on hold as B.C. delivery delayed again

New COVID-19 cases slowing in Fraser Health region

Provincial health officer Dr. Bonnie Henry talk about the next steps in B.C.’s COVID-19 Immunization Plan during a press conference at Legislature in Victoria, B.C., on Friday, January 22, 2021. Two more cases of the COVID-19 strain first identified in South Africa have been diagnosed in British Columbia, bringing the total to three as of Jan. 16.THE CANADIAN PRESS/Chad Hipolito
B.C. now has three cases of South African COVID-19 variant, six of U.K. strain

Both variants are thought to spread faster than earlier strains

Rodney and Ekaterina Baker in an undated photo from social media. The couple has been ticketed and charged under the Yukon’s <em>Civil Emergency Measures Act</em> for breaking isolation requirements in order to sneak into a vaccine clinic and receive Moderna vaccine doses in Beaver Creek. (Facebook/Submitted)
Great Canadian Gaming CEO resigns after being accused of sneaking into Yukon for vaccine

Rod Baker and Ekaterina Baker were charged with two CEMA violations each

Police discovered a makeshift nightclub in a Vancouver apartment on Jan. 23, 2021, and say it wasn’t the first time this month officers have been called to the unit over social gathering concerns. (Phil McLachlan - Capital News)
Doorman of makeshift ‘booze-can’ in Vancouver apartment fined; police look to court order

This marks the fourth complaint about social gatherings inside the apartment in January

Local musician and artist Daisy Melville created a watercolour portrait of U.S. Senator Bernie Sanders from the recent American inauguration, and with help from her mom, is now selling t-shirts and more with funds going to the Comox Valley Food Bank. Image submitted
Island artist turns Sanders inauguration meme into art for good

All proceeds from the sale of shirts, sweaters and more will go to the Comox Valley Food Bank

A Kelowna couple welcomed their Nooner baby in December. (Flytographer)
Kelowna couple welcomes baby girl from Hotel Zed Nooner campaign

Nicole and Alex will now have 18 years of free stays at the hotel

Most Read